BOOKS - The Vaccine: Inside the Race to Conquer the COVID-19 Pandemic
The Vaccine: Inside the Race to Conquer the COVID-19 Pandemic - Joe Miller January 1, 2021 PDF  BOOKS
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The Vaccine: Inside the Race to Conquer the COVID-19 Pandemic
Author: Joe Miller
Year: January 1, 2021
Format: PDF
File size: PDF 2.7 MB
Language: English



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The Vaccine Inside the Race to Conquer the COVID-19 Pandemic In mid-January 2020, Ugur Sahin, a renowned scientist and co-founder of BioNTech, made a bold prediction to his wife and long-time research partner, Ozlem Tureci: a vaccine against the then-unknown COVID-19 could be developed and safely injected into the arms of millions before the end of the year. This was no ordinary claim, as the scientific community had never attempted such a feat before. However, Sahin's confidence was built upon almost three decades of research, specifically in the field of messenger RNA (mRNA) technology, which he believed could revolutionize the way cancerous tumors were treated. The couple, who founded BioNTech together, faced widespread skepticism from their peers, but they were undeterred. They had spent years exploring the potential of mRNA, a volatile and overlooked molecule that could potentially turn the human body into its own pharmacy. With their cutting-edge technology and innovative approach, they were determined to develop a vaccine against COVID-19. As the pandemic spread globally, the need for a vaccine became more urgent than ever. The scientific community was under pressure to deliver a solution, and BioNTech was well-positioned to make it happen. The company's unique approach to vaccine development, combined with Sahin and Tureci's expertise, made them an attractive partner for Big Pharma. In just weeks, they developed twenty vaccine candidates, each one tailored to the specific needs of different populations.
Вакцина внутри гонки за победу над пандемией COVID-19 В середине января 2020 года Угур Сахин, известный ученый и соучредитель BioNTech, сделал смелый прогноз своей жене и давнему партнеру по исследованиям Озлему Туреси: вакцина против неизвестного тогда COVID-19 может быть разработана и безопасно введена в объятия миллионов до конца года. Это не было обычной претензией, так как научное сообщество никогда ранее не предпринимало попыток подобного подвига. Однако уверенность Сахина была основана на почти трех десятилетиях исследований, особенно в области технологии матричной РНК (мРНК), которая, по его мнению, может революционизировать методы лечения раковых опухолей. Пара, вместе основавшая BioNTech, столкнулась с широко распространенным скептицизмом со стороны сверстников, но их это не испугало. Они потратили годы на изучение потенциала мРНК, летучей и игнорируемой молекулы, которая потенциально может превратить организм человека в собственную аптеку. С их передовыми технологиями и инновационным подходом они были полны решимости разработать вакцину против COVID-19. Поскольку пандемия распространилась по всему миру, потребность в вакцине стала как никогда актуальной. Научное сообщество было вынуждено предоставить решение, и BioNTech имела все возможности для его реализации. Уникальный подход компании к разработке вакцин в сочетании с опытом Сахина и Туречи сделали их привлекательным партнером для Big Pharma. Всего за несколько недель они разработали двадцать кандидатов на вакцины, каждый из которых был адаптирован к конкретным потребностям различных групп населения.
Un vaccin à l'intérieur de la course pour vaincre la pandémie de COVID-19 À la mi-janvier 2020, Ugur Sahin, scientifique de renom et cofondateur de BioNTech, a fait un pronostic audacieux à sa femme et partenaire de recherche de longue date, Ozlem Turesi : un vaccin contre le COVID-19, alors inconnu, pourrait être développé et mis en sécurité dans les bras de millions d'ici avant la fin de l'année. Ce n'était pas une revendication habituelle, car la communauté scientifique n'avait jamais tenté un tel exploit auparavant. Cependant, la confiance de Sahin a été fondée sur près de trois décennies de recherche, en particulier dans le domaine de la technologie de l'ARN matriciel (ARNm), qui, selon lui, pourrait révolutionner les traitements des tumeurs cancéreuses. couple qui a fondé BioNTech a été confronté à un scepticisme généralisé de la part de ses pairs, mais cela ne les a pas effrayés. Ils ont passé des années à étudier le potentiel de l'ARNm, une molécule volatile et ignorée qui pourrait potentiellement transformer le corps humain en sa propre pharmacie. Avec leur technologie de pointe et leur approche innovante, ils étaient déterminés à développer un vaccin contre la COVID-19. La pandémie s'étant répandue dans le monde entier, la nécessité d'un vaccin est devenue plus urgente que jamais. La communauté scientifique a été forcée de fournir une solution, et BioNTech avait toutes les possibilités de la mettre en œuvre. L'approche unique de l'entreprise en matière de développement de vaccins, combinée au savoir-faire de Sahin et Tureci, en fait un partenaire attrayant pour Big Pharma. En quelques semaines, ils ont mis au point vingt candidats vaccins, chacun adapté aux besoins spécifiques des différentes populations.
Vacuna dentro de la carrera por derrotar la pandemia de COVID-19 A mediados de enero de 2020, Ugur Sahin, reconocido científico y cofundador de BioNTech, hizo un audaz pronóstico a su esposa y compañera de investigación de larga data, Slema Touresi: una vacuna contra la entonces desconocida COVID-19 podría ser desarrollada y administrada con seguridad en un abrazo de millones antes de fin de año. No era una reivindicación habitual, ya que la comunidad científica nunca antes había intentado una hazaña similar. n embargo, la confianza de Sahin se basó en casi tres décadas de investigación, especialmente en el campo de la tecnología del ARNm de matriz (ARNm), que, en su opinión, podría revolucionar los tratamientos para los tumores cancerosos. La pareja que fundó BioNTech juntos se encontró con un escepticismo generalizado por parte de sus compañeros, pero esto no les asustó. Pasaron estudiando el potencial del ARNm, una molécula volátil e ignorada que potencialmente podría transformar el cuerpo humano en su propia farmacia. Con su avanzada tecnología y su enfoque innovador, estaban decididos a desarrollar una vacuna contra la COVID-19. A medida que la pandemia se ha extendido por todo el mundo, la necesidad de una vacuna se ha vuelto más urgente que nunca. La comunidad científica se vio obligada a proporcionar una solución y BioNTech tenía todas las facilidades para implementarla. enfoque único de la compañía para el desarrollo de vacunas, combinado con la experiencia de Sahin y Turechi, los ha convertido en un socio atractivo para Big Pharma. En apenas unas semanas han desarrollado una veintena de candidatos a vacunas, cada uno adaptado a las necesidades específicas de las diferentes poblaciones.
Vacina dentro da corrida para vencer a pandemia COVID-19 Em meados de janeiro de 2020, Ugur Sahin, conhecido cientista e co-fundador do BioNTech, fez uma previsão ousada à sua mulher e parceiro de pesquisa de longa data, Ozlem Thuresee: a vacina contra o desconhecido então COVID-19 pode ser desenvolvida e colocada em segurança em milhões de pessoas até o final do ano. Não era uma reclamação comum, porque a comunidade científica nunca tinha tentado tal proeza. No entanto, a confiança de Sahin foi baseada em quase três décadas de pesquisa, especialmente na tecnologia de RNA matriz (MRNA), que, em sua opinião, pode revolucionar os tratamentos contra o câncer. O casal que fundou o BioNTech enfrentou ceticismo generalizado por parte de seus pares, mas isso não os assustou. Eles passaram anos estudando o potencial do mRNA, uma molécula volátil e ignorada que pode potencialmente transformar o corpo humano em uma farmácia própria. Com suas tecnologias avançadas e uma abordagem inovadora, eles estavam determinados a desenvolver uma vacina contra a COVID-19. Como a pandemia se espalhou pelo mundo, a necessidade da vacina tornou-se mais urgente do que nunca. A comunidade científica foi obrigada a dar uma solução, e BioNTech tinha toda a capacidade de implementá-la. A abordagem única da empresa no desenvolvimento de vacinas combinada com a experiência de Sahin e Tureci tornaram-nos um parceiro atraente para a Big Pharma. Em poucas semanas, eles desenvolveram vinte candidatos para vacinas, cada um adaptado às necessidades específicas de diferentes populações.
Il vaccino all'interno della corsa per la vittoria contro la pandemia COVID-19 A metà gennaio 2020 Ugur Sahin, noto scienziato e co-fondatore del BioNTech, ha fatto un'audace previsione alla moglie e ad un vecchio partner di ricerca, Ozlem Turesi, che il vaccino contro l'ignoto allora COVID-19 potrebbe essere sviluppato e messo in sicurezza tra le braccia di milioni di persone entro la fine dell'anno. Non era una rivendicazione ordinaria, perché la comunità scientifica non aveva mai tentato un tale exploit. Ma la fiducia di Sahin si è basata su quasi tre decenni di ricerca, in particolare nel campo della tecnologia RNA (Matrix RNA), che ritiene possa rivoluzionare le terapie per il cancro. La coppia che ha fondato la BioNTech ha affrontato un diffuso scetticismo da parte dei suoi coetanei, ma non li ha spaventati. Hanno passato anni a studiare il potenziale dell'RNA, una molecola volatile e ignorata che potenzialmente può trasformare il corpo umano in una propria farmacia. Con la loro tecnologia avanzata e il loro approccio innovativo, sono stati determinati a sviluppare un vaccino contro il COVID-19. Poiché la pandemia si è diffusa in tutto il mondo, il bisogno di vaccino è diventato più urgente che mai. La comunità scientifica è stata costretta a fornire una soluzione e la società ha avuto tutte le possibilità di realizzarla. L'approccio unico dell'azienda allo sviluppo di vaccini, insieme all'esperienza di Sahin e Turechi, li ha resi un partner attraente per Big Pharma. In poche settimane hanno sviluppato venti candidati per i vaccini, ognuno dei quali è stato adattato alle esigenze specifiche delle diverse popolazioni.
Impfstoff im Rennen um den eg über die COVID-19-Pandemie Mitte Januar 2020 machte Ugur Sahin, renommierter Wissenschaftler und Biontech-Mitgründer, seiner Frau und langjährigen Forschungspartnerin Özlem Turesi eine gewagte Prognose: Ein Impfstoff gegen das dann unbekannte COVID-19 könnte noch vor Jahresende entwickelt und sicher in die Arme von Millionen gespritzt werden. Dies war keine gewöhnliche Behauptung, da die wissenschaftliche Gemeinschaft noch nie zuvor einen Versuch einer solchen istung unternommen hatte. Sahins Vertrauen basierte jedoch auf fast drei Jahrzehnten Forschung, insbesondere auf dem Gebiet der Boten-RNA (mRNA) -Technologie, von der er glaubt, dass sie die Behandlung von Krebstumoren revolutionieren könnte. Das Paar, das gemeinsam Biontech gegründet hat, sah sich mit weit verbreiteter Skepsis von Gleichaltrigen konfrontiert, aber sie ließen sich davon nicht einschüchtern. e haben jahrelang das Potenzial von mRNA untersucht, einem flüchtigen und vernachlässigten Molekül, das den menschlichen Körper möglicherweise in eine eigene Apotheke verwandeln könnte. Mit ihrer fortschrittlichen Technologie und ihrem innovativen Ansatz waren sie entschlossen, einen Impfstoff gegen COVID-19 zu entwickeln. Mit der Ausbreitung der Pandemie auf der ganzen Welt ist der Bedarf an einem Impfstoff dringender denn je geworden. Die wissenschaftliche Gemeinschaft war gezwungen, eine Lösung zu liefern, und Biontech war gut aufgestellt, um sie umzusetzen. Der einzigartige Ansatz des Unternehmens bei der Entwicklung von Impfstoffen, kombiniert mit der Expertise von Sahin und Tureci, hat sie zu einem attraktiven Partner für Big Pharma gemacht. In nur wenigen Wochen entwickelten sie zwanzig Impfstoffkandidaten, die jeweils auf die spezifischen Bedürfnisse verschiedener Bevölkerungsgruppen zugeschnitten waren.
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COVID-19 pandemisini yenme yarışında aşı Ocak 2020'nin ortalarında, ünlü bir bilim insanı ve BioNTech'in kurucu ortağı olan Uğur Şahin, eşi ve uzun zamandır araştırma ortağı olan Özlem Turesi'ye cesur bir tahminde bulundu: O zamanlar bilinmeyen COVID-19'a karşı bir aşı geliştirilebilir ve yıl sonundan önce milyonlarca kişinin kollarına güvenle uygulanabilir. Bu yaygın bir iddia değildi, çünkü bilim camiası daha önce hiç böyle bir girişimde bulunmamıştı. Bununla birlikte, Şahin'in güveni, özellikle kanser terapilerinde devrim yaratabileceğine inandığı mesajcı RNA (mRNA) teknolojisi alanında yaklaşık otuz yıllık bir araştırmaya dayanıyordu. BioNTech'i birlikte kuran çift, akranlarından yaygın şüphecilikle karşı karşıya kaldı, ancak yılmadılar. İnsan vücudunu potansiyel olarak kendi eczanesine dönüştürebilecek uçucu ve göz ardı edilen bir molekül olan mRNA'nın potansiyelini incelemek için yıllarını harcadılar. İleri teknolojileri ve yenilikçi yaklaşımlarıyla COVID-19'a karşı bir aşı geliştirmeye kararlıydılar. Pandemi tüm dünyaya yayıldıkça, aşı ihtiyacı her zamankinden daha acil hale geldi. Bilimsel topluluk bir çözüm sağlamak zorunda kaldı ve BioNTech bunu uygulamak için iyi bir yerdeydi. Şirketin aşı geliştirme konusundaki benzersiz yaklaşımı, Şahin ve Tureci'nin uzmanlığı ile birleştiğinde, onları Big Pharma için cazip bir ortak haline getirdi. Sadece birkaç hafta içinde, her biri farklı popülasyonların özel ihtiyaçlarına göre uyarlanmış yirmi aşı adayı geliştirdiler.
لقاح داخل السباق لهزيمة جائحة COVID-19 في منتصف يناير 2020، قدم أوغور شاهين، العالم الشهير والمؤسس المشارك لشركة BioNTech، تنبؤًا جريئًا لزوجته وشريكه البحثي منذ فترة طويلة أوزليم توريسي: يمكن تطوير لقاح ضد كوفيد-19 غير المعروف آنذاك وإدخاله بأمان في أحضان الملايين قبل نهاية العام. لم يكن هذا ادعاءً شائعًا، حيث لم يحاول المجتمع العلمي مثل هذا العمل الفذ من قبل. ومع ذلك، استندت ثقة Sahin إلى ما يقرب من ثلاثة عقود من البحث، لا سيما في مجال تقنية الحمض النووي الريبي (mRNA)، والتي يعتقد أنها يمكن أن تحدث ثورة في علاجات السرطان. واجه الزوجان، اللذان أسسا BioNTech معًا، شكوكًا واسعة النطاق من أقرانهما، لكنهما لم يردعا. لقد أمضوا سنوات في دراسة إمكانات mRNA، وهو جزيء متقلب ومتجاهل يمكن أن يحول جسم الإنسان إلى صيدلية خاصة به. من خلال تقنياتهم المتقدمة ونهجهم المبتكر، كانوا مصممين على تطوير لقاح ضد COVID-19. مع انتشار الوباء في جميع أنحاء العالم، أصبحت الحاجة إلى لقاح أكثر إلحاحًا من أي وقت مضى. اضطر المجتمع العلمي إلى تقديم حل، وكان BioNTech في وضع جيد لتنفيذه. لقد جعلهم نهج الشركة الفريد لتطوير اللقاحات، جنبًا إلى جنب مع خبرة Sahin و Tueri، شريكًا جذابًا لشركة Big Pharma. في غضون أسابيع قليلة فقط، طوروا عشرين لقاحًا مرشحًا، تم تصميم كل منها وفقًا للاحتياجات المحددة لمختلف السكان.

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